The enzymic composition of nuclei isolated from radio-sensitive and non-sensitive tissues with special reference to catalase activity

Abstract

A study has been made of the enzyme content of cell nuclei isolated from both radio-sensitive and non-sensitive tissues of the rat and from pigeon liver in an attempt to demonstrate a biochemical basis for differences in radio-sensitivity. Catalase activity was found to be much greater in the nuclei from non-sensitive tissues. Total body radiation led to a decrease in nuclear-catalase content, but no significant change in the activity of whole lymphatic tissues. The nuclear effect could be correlated with the dose of radiation received. Radiation of nuclear suspensions of thymus led to a decrease in activity.