Action of Vasopressin on the Permeability of Mesentery

Abstract

Contemporaneous movements of Rb86 cations and of P³² orthophosphate across isolated rabbit mesentery display kinetic patterns that are generally associated with passive diffusion. Vasopressin at a concentration of 100 milliunit/ml produced a significant increase in the permeability constant for P³² and at the same time a significant decrease in the permeability to Rb⁸⁶. At lower hormone concentrations (0.1 milliunit/ml) the P32 response was less marked but still significant (P < .01), while the Rb⁸⁶ effect was not (P > .05). Hyaluronidase did not mimic these actions of vasopressin.