PRESSURE REVERSAL OF GENERAL ANAESTHESIA—A MULTI-SITE EXPANSION HYPOTHESIS
Open Access
- 1 November 1978
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 50 (11), 1091-1097
- https://doi.org/10.1093/bja/50.11.1091
Abstract
We have quantitated the pressure reversal of continuous i.v. anaesthesia produced in rats by keta-mine, methohexitone, propanidid and thiopentone. These and other data are not consistent with the earlier critical volume hypothesis of general anaesthesia and therefore we postulate an alternative molecular mechanism—the multi-site expansion hypothesis.This publication has 4 references indexed in Scilit:
- The Pressure Reversal of a Variety of Anesthetic Agents in MiceAnesthesiology, 1978
- High pressure and intravenous steroid anesthesia in ratsJournal of Applied Physiology, 1977
- PRESSURE ANTAGONISM TO NERVE-CONDUCTION BLOCK BY ANESTHETIC AGENTS1977
- Pressure reversal of the action of certain narcoticsJournal of Cellular and Comparative Physiology, 1942