Structure of pentameric human serum amyloid P component
- 1 January 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 367 (6461), 338-345
- https://doi.org/10.1038/367338a0
Abstract
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.Keywords
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