The mesitylene-2-sulphonyl group, an acidolytically removable N G -protecting group for arginine

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Abstract
The mesitylene-2-sulphonyl (Mts) group attached at the guanidino function of arginine can be quantitatively cleaved by methanesulphonic acid, as well as trifluoromethanesulphonic acid and hydrogen fluoride; this new Arg(Mts) derivative was successfully applied to the synthesis of hypothalamic substance P.