Agranulocytosis and Jaundice during Therapy with Meprobamate and Promazine

Abstract

IT is now well recognized that tranquilizing drugs are capable of producing a variety of untoward reactions, some major and some minor. In an effort to eliminate or at least to minimize such reactions the producers of these drugs have developed an increasing number of analogues, which, they hoped, would be less toxic than the original preparations. More recently, in keeping with the current trend toward proprietary drug combinations,¹ mixtures of these drugs have been prepared and tested. One of these mixtures is a combination of meprobamate with promazine.‡ The purpose of this paper is to report 3 cases of . . .