Plasma lipids and urinary excretion of catecholamines in man during experimentally induced emotional stress, and their modification by nicotinic acid
Open Access
- 1 August 1968
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 47 (8), 1795-1805
- https://doi.org/10.1172/jci105869
Abstract
33 male volunteers were studied in the morning after fasting overnight. 11 (the control group) were allowed to sit comfortably for three consecutive 2-hr periods, no stressors or treatment being introduced. The remaining 22 were divided into two groups, each being exposed to standardized, emotional stressors during the second of the three 2-hr periods. The subjects in one of these groups were each given a total dose of 3 g of nicotinic acid during the first 3 hr of the experiment, whereas the other group received no treatment. Stress was accompanied and followed by increased levels of free fatty acids and triglycerides in arterial plasma, by an increase in catecholamine excretion, and a rise in heart rate and systolic and diastolic blood pressure. No such increases were seen in the control group. The stress-induced rise in free fatty acids was inhibited by nicotinic acid, and the triglyceride rise was turned into a fall. The stressor-induced increase in catecholamine excretion was not significantly affected by nicotinic acid, neither were the increases in heart rate and blood pressure. The hypothesis is discussed, from a qualitative as well as a quantitative viewpoint, that there is a direct relationship between the increased concentration of free fatty acids accompanying emotional stress in man and the eventual development of the stress hyperlipoproteinemia.This publication has 30 references indexed in Scilit:
- INHIBITION OF THE MOBILIZATION OF FREE FATTY ACIDS FROM ADIPOSE TISSUE*Annals of the New York Academy of Sciences, 1965
- Studies on the Effect of Nicotinic Acid on Catecholamine Stimulated Lipolysis in Adipose Tissue in VitroActa Medica Scandinavica, 1963
- EFFECT OF NICOTINIC ACID ON TURNOVER RATE AND OXIDATION OF FREE FATTY ACIDS OF PLASMA IN MAN DURING EXERCISE1963
- RELATIONSHIP OF PERIODIC MENTAL STRESS TO SERUM LIPOPROTEIN AND CHOLESTEROL LEVELSJAMA, 1959
- Acute Effect of Psychologic Stimuli upon Plasma Non-Esterified Fatty Acid Level.Experimental Biology and Medicine, 1959
- The Metabolism of Albumin Bound C14-Labeled Unesterified Fatty Acids in Normal Human SubjectsJCI Insight, 1958
- Changes in the Serum Cholesterol and Blood Clotting Time in Men Subjected to Cyclic Variation of Occupational StressCirculation, 1958
- Influence of nicotinic acid on serum cholesterol in manArchives of Biochemistry and Biophysics, 1955
- Determination of Urinary CorticosteroidsNature, 1952
- A REVISION OF THE SCHOENHEIMER-SPERRY METHOD FOR CHOLESTEROL DETERMINATIONJournal of Biological Chemistry, 1950