In vivo 31 P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia
- 1 November 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (11), 1423
- https://doi.org/10.1212/wnl.39.11.1423
Abstract
We used in vivo phosphorus 31 nuclear magnetic resonance (31P NMR) spectroscopy to study regional high-energy phosphate and phospholipid metabolism in brains of patients with dementia associated with probable Alzheimer's disease (AD) and multiple subcortical cerebral infarctions (MSID). The MSID patients demonstrated elevations of the phosphocreatine (PCr)/inorganic orthophosphate (Pi) ratio in both the temporoparietal and frontal regions. Phosphomonoesters (PME) and the ratio of PME to phosphodiesters were elevated in the temporoparietal region of AD. Pi was also elevated in the frontal and temporoparietal regions of AD. Findings from 31P NMR were accurate in distinguishing MSID from AD. Values of PCr/Pi accurately classified 100% of the MSID patients and 92% of AD. Pi and PME, considered jointly, also accurately classified all MSID and all but 1 AD. Findings from in vivo 31P NMR spectroscopy appear to yield metabolic profiles useful in distinguishing AD from MSID.This publication has 9 references indexed in Scilit:
- Correlation of Phosphorus-31 Magnetic Resonance Spectroscopy and Morphologic Findings in Alzheimer's DiseaseArchives of Neurology, 1988
- 31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs DiseaseJournal of Neuropathology and Experimental Neurology, 1988
- 31P Nuclear Magnetic Resonance Studies of Phosphoglyceride Metabolism in Developing and Degenerating BrainJournal of Neuropathology and Experimental Neurology, 1987
- Improved cognition after control of risk factors for multi-infarct dementiaJAMA, 1986
- Plasticity of Hippocampal Circuitry in Alzheimer's DiseaseScience, 1985
- Comparison of glucose metabolism, x‐ray CT, and postmortem data in a patient with multiple cerebral infarctsNeurology, 1985
- Cerebral intracellular pH by 31 P nuclear magnetic resonance spectroscopyNeurology, 1985
- Diagnostic evaluation of degenerative and vascular dementia.Stroke, 1983
- Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementiaBrain Research, 1981