Intravenous miconazole therapy for experimental keratomycosis in rabbits

Abstract

Intravenous miconazole (90 mg daily for 3 weeks) reduced the intensity of experimental fungal keratitis due to Candida albicans in a group of 10 rabbits. Clinical scores of affected eyes were statistically significantly lower in the treated group than in a control group of 10 untreated rabbits. All cultures of corneal scrapings were negative on 18th day after inoculation in the treated group, but four cultures were still positive on the 21st day in the control animals. Histopathological examination of eyes from treated and untreated rabbits showed great differences in the severity of inflammatory changes in the two groups. Miconazol, intravenoes gegeben (90 mg taeglich fuer 3 Wochen), reduziert die Intensitaet der experimentellen Candida albicans—Keratitis in einer Versuchsgruppe von 10 Kaninchen. Die klinischen Befunde waren bei den Miconazol behandelten Tieren statistisch gesichert geringer als bei einer unbehandelten Kontrollgruppe von 10 Kaninchen. Nach 18 Tagen waren in der Versuchsgruppe alle Abstriche kulturell negativ waehrend in der Kontrollgruppe nach 21 Tagen noch 4 Abstriche positiv waren. Das Ansmass der Entzuendung zeigte histopathologisch auffaellige Differenzen zwischen den beiden Gruppen.