Atrophic gastritis in young children and adolescents
Open Access
- 27 October 2005
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 58 (11), 1189-1193
- https://doi.org/10.1136/jcp.2005.026310
Abstract
Background:Helicobacter pylori associated gastric cancer arises via a multistage process, with atrophic gastritis being the precursor lesion. Helicobacter pylori is typically acquired in childhood, yet little is known of the prevalence of atrophic gastritis in childhood. Aim: To study atrophic gastritis among children from countries with high gastric cancer incidence. Methods: Sections from topographically mapped gastric biopsy specimens from children undergoing clinically indicated endoscopy in Korea and Colombia were evaluated using visual analogue scales. Atrophy was defined as loss of normal glandular components, including replacement with fibrosis, intestinal metaplasia (IM), and/or pseudopyloric metaplasia of the corpus (identified by the presence of pepsinogen I in mucosa that was topographically corpus but phenotypically antrum). Results: One hundred and seventy three children, 58 from Korea (median age, 14 years) and 115 from Colombia (median age, 13 years), were studied. Helicobacter pylori was present in 85% of Colombian children versus 17% of Korean children (pConclusion: Gastric atrophy occurs in H pylori infected children living in countries with high gastric cancer incidence. Identification and characterisation of the natural history of H pylori gastritis requires targeted biopsies to include the lesser and greater curve of the corpus, starting just proximal to the anatomical antrum–corpus junction, in addition to biopsies targeting the antrum and cardia.Keywords
This publication has 44 references indexed in Scilit:
- Early events in proton pump inhibitor‐associated exacerbation of corpus gastritisAlimentary Pharmacology & Therapeutics, 2003
- Gastric mucosal atrophy: interobserver consistency using new criteria for classification and gradingAlimentary Pharmacology & Therapeutics, 2002
- Patterns of gastric atrophy in intestinal type gastric carcinomaCancer, 2002
- The African Enigma: Low Prevalence of Gastric Atrophy, High Prevalence of Chronic Inflammation in West African Adults and ChildrenHelicobacter, 2001
- Helicobacter pylori Infection and Recurrent Abdominal Pain in Turkish ChildrenHelicobacter, 2001
- Gastric intestinal metaplasia: subtypes and natural historyJournal of Clinical Pathology, 2001
- Geographic differences in the distribution of intestinal metaplasia in duodenal ulcer patientsAmerican Journal of Gastroenterology, 2001
- Pediatric Gastrointestinal Mucosal Biopsy: Special Considerations in ChildrenGastrointestinal Endoscopy Clinics of North America, 2000
- Clinical and Pathological Importance of cagA‐Positive Helicobacter pylori Strains in Children with Abdominal ComplaintsHelicobacter, 1999
- Carcinoma and Intestinal Metaplasia of the Stomach in Colombian Migrants2JNCI Journal of the National Cancer Institute, 1970