Biomaterial-Centered Sepsis and the Total Artificial Heart
- 12 February 1988
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 259 (6), 870-874
- https://doi.org/10.1001/jama.1988.03720060038027
Abstract
The principal barrier to the extended use of the total artificial heart is infection that is centered on the biomaterial constituting the prosthetic device and exacerbated by the surrounding damaged tissue. Ultrastructural studies of total artificial hearts removed from two patients indicate a failure of true tissue integration and diffuse, adhesive bacterial colonization of biomaterial surfaces. Biomaterials are, in part, susceptible to infection because, at the present state of the art, they are usually not well integrated with host tissue or, if hemodynamic, not optimally biocompatible or antiadhesive. (JAMA1988;259:870-874)Keywords
This publication has 5 references indexed in Scilit:
- The Interaction Between Pseudomonas aeruginosa and the Corneal EpitheliumArchives of Ophthalmology (1950), 1985
- Comparison of ceramic and titanium implants in catsActa Orthopaedica, 1984
- Bacterial Adherence: Adhesin-Receptor Interactions Mediating the Attachment of Bacteria to Mucosal SurfacesThe Journal of Infectious Diseases, 1981
- Adherence of Marine Micro-organisms to Smooth SurfacesPublished by Springer Nature ,1980
- Identification, localization, and role of fibronectin in cultured bovine endothelial cells.Proceedings of the National Academy of Sciences, 1978