Phytate and zinc bioavailability
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in International Journal of Food Sciences and Nutrition
- Vol. 46 (1), 53-63
- https://doi.org/10.3109/09637489509003386
Abstract
This review discusses evidence from human studies on the effects of dietary phytate on zinc bioavailability. In vitro and animal experiments have implicated calcium as a potentiating factor because it reacts with phytate, and zinc binds to the precipitate. Magnesium also reacts similarly to calcium, but most studies have not considered this factor. Protein provides amino acids, some of which are able to desorb zinc from the precipitate and improve bioavailability. Some predictive ratios, derived from animal studies, have been directly applied to human studies. The studies reviewed included those on: zinc status of groups, apparent absorption of zinc in normal subjects and ileostomists, true absorption using a stable isotope, plasma tolerance, and the accumulation in the body of a radioisotope. It was concluded that detrimental effects of phytate could be demonstrated on zinc bioavailability, but that the studies had not been designed specifically to demonstrate whether the interactions found in animal studies also apply to humans. It is suggested that more targeted research is required before predictive ratios are used for humans.Keywords
This publication has 34 references indexed in Scilit:
- Dietary phytate × calcium/zinc millimolar ratios and zinc nutriture in some Ontario preschool childrenBiological Trace Element Research, 1991
- Binding differences of Zn(II) and Cu(II) ions with phytateJournal of Inorganic Biochemistry, 1990
- Dietary calcium, phytate, and zinc intakes and the calcium, phytate, and zinc molar ratios of the diets of a selected group of East African childrenThe American Journal of Clinical Nutrition, 1989
- Phytic Acid Interactions with Divalent Cations in Foods and in the Gastrointestinal TractPublished by Springer Nature ,1989
- Zinc in Human NutritionNutrition Research Reviews, 1988
- Phytate × Calcium/Zinc Molar Ratios: Are They Predictive of Zinc Bioavailability?Journal of Food Science, 1987
- [Phytate][calcium]/[zinc] ratios in Asian immigrant lacto-ovo vegetarian diets and their relationship to zinc nutritureNutrition Research, 1986
- Mineral contents of brans passed through the human GI tractThe American Journal of Clinical Nutrition, 1985
- Effects of Dietary Phytate, Calcium and Magnesium Levels on Zinc Bioavailability to RatsJournal of Nutrition, 1984
- Phytic acid interactions in food systemsC R C Critical Reviews in Food Science and Nutrition, 1980