Variability of the response to activated protein C during normal pregnancy

Abstract

The response to activated protein C (APC) was investigated in 28 healthy women, non-carriers of the Arg506-Gln mutation in factor V, throughout pregnancy (gestation weeks 12, 20, 28, 32 and 37) and after the delivery. A suppression of APC response was observed which reached lowest values by week 28 (nAPC-ratio 0.78 ± 0.13), sustained low up to the end of pregnancy and rose after delivery (1.11 ± 0.22; P