The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs
Open Access
- 1 May 1972
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 45 (1), 37-47
- https://doi.org/10.1111/j.1476-5381.1972.tb09574.x
Abstract
1 . Slices of rabbit spleen generate rabbit aorta contracting substance (RCS) and a prostaglandin of the E series when they are vibrated or stirred. 2 . The release of both substances is increased by arachidonic acid and inhibited by aspirin-like drugs. 3 . When the spleen effluent containing RCS and prostaglandin E is incubated for a further 3 min, the prostaglandin concentration increases and the RCS concentration declines. 4 . RCS may therefore be an unstable intermediate in the biosynthesis of prostaglandins.Keywords
This publication has 20 references indexed in Scilit:
- Polyhydroxy cyclic ethers formed from tritiated arachidonic acid by acetone powders of sheep seminal vesiclesBiochemistry, 1971
- Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenatesBiochemistry, 1971
- THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUESAnnals of the New York Academy of Sciences, 1971
- Release of Vasoactive Substances from Guinea-Pig Lungs by Slow-Reacting Substance C and Arachidonic AcidPharmacology, 1971
- Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory DrugsNature, 1969
- Prostaglandins released by the SpleenNature, 1968
- THE OCCURRENCE OF PROSTAGLANDIN E2 IN SPLENIC VENOUS BLOOD OF THE DOG FOLLOWING SPLENIC NERVE STIMULATIONBritish Journal of Pharmacology, 1968
- Prostaglandins: Their Disappearance from and Release into the CirculationNature, 1967
- A SENSITIVE METHOD FOR THE ASSAY OF ANGIOTENSINBritish Journal of Pharmacology and Chemotherapy, 1964
- A SENSITIVE METHOD FOR THE ASSAY OF 5‐HYDROXYTRYPTAMINEBritish Journal of Pharmacology and Chemotherapy, 1957