Reduced Survival Time in Descendants of Five Generations of X-Irradiated Sires

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Abstract
The life span of nonirradiated descendants of 5 generations of X-irradiated sires was found to be significantly less than that of mice with the same degree of inbreeding but from ancestors with no history of exposure to ionizing radiation. This was attributed to accumulated genetic damage but might conceivably have been due to chance genetic selection at the time the separate lines were established.