Variable Decay of Memory and Its Recovery in Cycloheximide-Treated Mice
- 1 June 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (6), 1416-1420
- https://doi.org/10.1073/pnas.69.6.1416
Abstract
Mice were trained in an automated visual-discrimination task. When injected with cycloheximide before training, mice showed: (a) some impairment of memory within minutes after the beginning of training, (b) gradual development of total amnesia in less than 3 hr or in more than 6 hr after training, depending on the extent of training, and (c) spontaneous recovery of memory within 3 days after training. The results are consistent with the operation of three processes of memory storage: (i) a short-term process that is independent of protein synthesis, (ii) a long-term that is dependent on protein synthesis, and (iii) a slow-developing memory storage that becomes apparent during the days after training.Keywords
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