Atherogenic hyperlipoproteinemia induced by cholesterol feeding in the Patas monkey

Abstract

Patas monkeys [Erythrocebus patas] were studied for 2 yr on 3 dietary regimes: commercial chow (control diet), semipurified diet plus lard (fat-fed), and semipurified diet plus lard and cholesterol (cholesterol-fed). The control and fat-fed animals had similar lipoproteins which were equivalent to the human very low density lipoprotein [VLDL], low density lipoprotein (LDL), and high density lipoproteins. An additional lipoprotein referred to as LDL-II appeared to be equivalent to the human lipoprotein(a). The cholesterol-fed animals developed accelerated atherosclerosis associated with a hypercholesterolemia which was characterized by the appearance of .beta.-migrating lipoproteins (B-VLDL) in the d < 1.006, an increase in the intermediate lipoproteins and LDL and the appearance of LDL-II which contained a prominence of the arginine-rich apoprotein. The arginine-rich apoprotein was also a prominent component of the B-VLDL and intermediate lipoproteins. This apoprotein contained 11.5 mol % arginine, had a MW of .apprx. 34,000, and coelectrophoresed with the arginine-rich apoprotein of human, dog, swine, rat and rabbit.