HLA-DR AND HLA-DQ DNA GENOTYPING IN INSULIN-DEPENDENT DIABETES PATIENTS IN SOUTH-INDIA

Abstract

Restriction fragment length polymorphisms (RFLPs) of the HLA-DR.beta., -DQ.alpha., DQ.beta., and -DX.alpha. genes have been examined in South Indian diabetic patients and controls. The DR, DQ linkage arrangements in South Indians were shown to be different for DR2, DR4, and DRw6 from those commonly seen in Europeans, so that localization of the primary disease-promoting gene in IDDM could be attempted. This study clearly implicates at least one DQ.beta. allele in the pathogenesis of IDDM.