Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acids

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Abstract
A series of 6,11-dihydrodibenz[b,e]oxepin-2-acetic acids were evaluated for both anti-inflammatory and analgetic activity in the carrageenan [rat] paw edema and phenylquinone writhing assays. The requirements for optimal activity in this series appear rather specific: an unsubstituted 6,11-dihydrodibenz[b,e]oxepin nucleus and a carbonyl group in the 11 position. One derivative, 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid, was selected for further study.