Capillary Abnormalities in Polyvinyl Chloride Production Workers
- 20 September 1976
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 236 (12), 1368-1371
- https://doi.org/10.1001/jama.1976.03270130030022
Abstract
Examination by wide-field capillary microscopy of the hands of 152 workers in vinyl chloride (VC) polymerization plants demonstrated scattered, scleroderma-like microvascular abnormalities in 21 workers and isolated capillary abnormalities in 27, as compared with only three isolated abnormalities in 50 manual workers not exposed to vinyl chloride. Thirteen of 17 VC workers with objective evidence of VC-associated abnormalities (angiosarcoma or fibrosis of liver, acroosteolysis, or scleroderma-like skin lesions) were observed to have microvascular abnormalities. If prospective studies confirm the implications of this study, capillary microscopy may become a useful mass-screening procedure in the early detection and prevention of VC-associated disease. (JAMA236:1368-1371, 1976)Keywords
This publication has 4 references indexed in Scilit:
- CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE: CURRENT RESULTSAnnals of the New York Academy of Sciences, 1975
- Patterns of finger capillary abnormalities in connective tissue disease by “wide‐field” microscopyArthritis & Rheumatism, 1973
- “Wide-field” photography of nailfold capillary bed and a scale of plexus visualization scores (PVS)Microvascular Research, 1970
- Acro-osteolysis occurring in men engaged in the polymerization of vinyl chloride.BMJ, 1967