Recombinant Human Leptin in Women with Hypothalamic Amenorrhea
Top Cited Papers
- 2 September 2004
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 351 (10), 987-997
- https://doi.org/10.1056/nejmoa040388
Abstract
Disruptions in hypothalamic–gonadal and other endocrine axes due to energy deficits are associated with low levels of the adipocyte-secreted hormone leptin and may result in hypothalamic amenorrhea. We hypothesized that exogenous recombinant leptin replacement would improve reproductive and neuroendocrine function in women with hypothalamic amenorrhea.Keywords
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