Inhibition of Aldosterone Secretion by Amphenone in Man
- 3 January 1957
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 256 (1), 16-21
- https://doi.org/10.1056/nejm195701032560104
Abstract
AMPHENONE was synthesized in 1950 by Allen and Corwin1 and has been shown to possess a high degree of biologic activity in animals2 3 4 and man.5 6 7 In animals the compound has been shown to affect the uterus and the thyroid and the adrenal glands. In man the studies carried out to date have been limited to its effects on the thyroid gland and on the adrenal cortex. The thyroid effects are qualitatively similar to those of thiourea and primarily result in inhibition of the organic binding of iodine.5 , 8 The adrenal effects appear at present to result from an inhibitory action of . . .Keywords
This publication has 8 references indexed in Scilit:
- AMPHENONE INHIBITION OF ADRENAL CORTICOSTEROID OUTPUT IN THE HYPOPHYSECTOMIZED DOGEndocrinology, 1956
- AMPHENONE: TOXICITY AND EFFECTS ON ADRENAL AND THYROID FUNCTION IN MANJournal of Clinical Endocrinology & Metabolism, 1956
- Inhibition of Corticosteroid Secretion by Amphenone in a Patient with Adrenocortical CarcinomaNew England Journal of Medicine, 1956
- Specific Enzymatic Determination of Glucose in Blood and Urine Using Glucose OxidaseDiabetes, 1956
- CORTICOSTEROID SECRETION IN THE ADRENAL VENOUS BLOOD OF THE HYPOPHYSECTOMIZED DOG AS AN ASSAY FOR ACTH1Endocrinology, 1955
- PHYSICOCHEMICAL DETECTION AND MEASUREMENT OF ALDOSTERONE IN BODY FLUIDS AND TISSUESActa Endocrinologica, 1955
- THE DETERMINATION OF URINARY STEROIDS. I. THE PREPARATION OF PIGMENT-FREE EXTRACTS AND A SIMPLIFIED PROCEDURE FOR THE ESTIMATION OF TOTAL 17-KETOSTEROIDSJournal of Clinical Endocrinology & Metabolism, 1952
- The Electrolytic Reduction of p-Aminoacetophenone1Journal of the American Chemical Society, 1950