AMPHENONE INHIBITION OF ADRENAL CORTICOSTEROID OUTPUT IN THE HYPOPHYSECTOMIZED DOG

Abstract

The rate of 17-hydroxycorticosteroid output in the adrenal vein of the hypophysectomized dog in response to a 10-milliunit-dose of ACTH was markedly depressed following treatment with (2,2-bis -(p-aminophenyl)-2-methyl propanone-1-dihychochloride). Stilbestrol dipotassium sulfonate used for comparison with amphenone showed no corticosteroid production persisted as much as 3 hours after treatment In the intact dog after the initial corticosteroid depressant action of amphenone, there is a fairly rapid return of corticosteroid output to a pretreatment level. A similar pattern is seen in dogs receiving massive doses of ACTH.