Ultrastructure of Paired Helical Filaments of Alzheimerʼs Neurofibrillary Tangle
- 1 November 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 43 (6), 643-656
- https://doi.org/10.1097/00005072-198411000-00008
Abstract
Isolated paired helical filaments (PHF) of Alzheimer's disease and senile dementia of the Alzheimer type (AD/SDAT) were studied by negative stain techniques and electron microscopy (EM). The helical structure of the PHF was confirmed by tilt analysis of negatively stained isolated PHF. A substructure of four protofilaments, each 3–5 nm in diameter, was also observed. A comparison of PHF substructure, neurofilaments and microtubules, revealed no similarity among the three structures.This publication has 11 references indexed in Scilit:
- Neurofibrillary Changes in Human BrainJournal of Neuropathology and Experimental Neurology, 1983
- Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaquesActa Neuropathologica, 1983
- Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and UreaScience, 1982
- SENILE CEREBRAL AMYLOID - PRE-ALBUMIN AS A COMMON CONSTITUENT IN THE NEURITIC PLAQUE, IN THE NEUROFIBRILLARY TANGLE, AND IN THE MICRO-ANGIOPATHIC LESION1982
- An Immunoperoxidase Study of Senile Cerebral Amyloidosis with Pathogenetic ConsiderationsJournal of Neuropathology and Experimental Neurology, 1981
- IMMUNO-CYTOCHEMICAL STUDIES OF NEUROFIBRILLARY TANGLES1981
- Abnormal fibrils from scrapie-infected brainActa Neuropathologica, 1981
- EVIDENCE THAT ALZHEIMER NEUROFIBRILLARY TANGLES ORIGINATE FROM NEUROTUBULESThe Lancet, 1979
- Presence of neurofilament protein in Alzheimer's neurofibrillary tangles (ANT)Acta Neuropathologica, 1979
- Paired Helical Filaments in Electron Microscopy of Alzheimer's DiseaseNature, 1963