Changes in drug-metabolizing activities in the livers of suckling rats as a result of treatment of the lactating mothers with phenobarbitone and chlorpromazine
- 1 March 1971
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 122 (1), 41-47
- https://doi.org/10.1042/bj1220041
Abstract
1. Lactating female rats were treated with phenobarbitone or chlorpromazine. 2. Hepatic microsomal fractions from the suckling offspring were studied to see if changes had occurred in the rates of drug metabolism. 3. Treatment with phenobarbitone significantly increased the cytochrome P-450 concentration, the activity of NADPH–cytochrome c reductase (EC 1.6.2.3) and the rates of metabolism of aniline, ethylmorphine and [2-14C]pentobarbitone. 4. Treatment with chlorpromazine produced only small increases in the cytochrome P-450 concentration and the rate of hydroxylation of aniline.Keywords
This publication has 26 references indexed in Scilit:
- Some in vitro assay conditions that affect detection and quantitation of phenobarbital-induced increases in hepatic microsomal drug-metabolizing enzyme activityToxicology and Applied Pharmacology, 1970
- Lipid peroxide formation in microsomes. Relationship of hydroxylation to lipid peroxide formationBiochemical Journal, 1969
- Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.1969
- Changes in Michaelis and spectral constants for aniline in hepatic microsomes from phenobarbital-treated rats.1969
- DIFFUSION OF CERTAIN WEAK ORGANIC ACIDS AND BASES ACROSS BOVINE MAMMARY GLAND MEMBRANE AFTER SYSTEMIC ADMINISTRATION1967
- Possible Role of P-450 in the Oxidation of Drugs in Liver Microsomes*The Journal of Biochemistry, 1966
- Differences in Hepatic Drug Metabolism in Various Rabbit Strains Before and After Pretreatment with Phenobarbital.Experimental Biology and Medicine, 1965
- THE MECHANISM OF DRUG SECRETION INTO BOVINE MILKAnnals of the New York Academy of Sciences, 1964
- Microsomal Triphosphopyridine Nucleotide-Cytochrome c Reductase of LiverJournal of Biological Chemistry, 1962
- BIOCHEMICAL AND PHARMACOLOGICAL CHANGES IN THE RAT FOLLOWING CHRONIC ADMINISTRATION OF MORPHINE, NALORPHINE AND NORMORPHINE1959