Inhibition of prostaglandin biosynthesis by 7-oxa- and 5-oxa-prostaglandin analogues (Short Communication)
- 15 January 1973
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 132 (1), 117-120
- https://doi.org/10.1042/bj1320117
Abstract
Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure–activity relationships were ascertained.Keywords
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