A method for bioassay of physical dependence on sedative drugs in dog
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 47 (1), 7-15
- https://doi.org/10.1007/bf00428694
Abstract
A method for an economical bioassay of physical dependence on sedatives is presented. Dogs maintained on sodium pentobarbital (200 mg/kg/24 h i.v.) were given periodic graded reductions in maintenance dose, and subscales for measuring signs of abstinence were developed. Using these subscales the relative potencies compared with sodium pentobarbital were determined for sodium secobarbital (RP=0.85) and methaqualone (RP=0.14). Sodium thiopental and methaqualone were assayed and found to be equipotent (RP=0.96) in reducing the signs of abstinence from sodium pentobarbital. The occurrence of convulsions, during periods of complete reduction of the maintenance drug, became less frequent the longer the dogs had been maintained on a constant dose of sodium pentobarbital.This publication has 19 references indexed in Scilit:
- A simple screening test for drugs of potential use in ethanol withdrawalJournal of Pharmacy and Pharmacology, 1973
- Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal ReactionScience, 1971
- Alcohol Withdrawal Syndrome in MiceArchives of Neurology, 1969
- A Substitution Technique for Determining Barbiturate-like Physiological Dependence Capacity in the Dog1Pharmacopsychiatry, 1968
- Quantitative Analysis of the Effect of Methaqualone on the Human EEGThe Journal of Clinical Pharmacology and The Journal of New Drugs, 1968
- Mandrax poisoning: conservative management of 116 patients.BMJ, 1968
- Poisoning with MandraxBMJ, 1966
- Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained RatsScience, 1962
- Convulsions in cats following withdrawal of barbital sodiumExperimental Neurology, 1959
- Relationship Between Sleep, Biotransformation Rates, and Plasma Levels of Pentobarbital and Secobarbital in AnimalsExperimental Biology and Medicine, 1957