2‐Pyrrolidinone in Human Cerebrospinal Fluid: A Major Constituent of Total γ‐Aminobutyric Acid
- 1 November 1987
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 49 (5), 1402-1406
- https://doi.org/10.1111/j.1471-4159.1987.tb01006.x
Abstract
2-Pyrrolidinone, the lactam of γ-aminobutyric acid (GABA), is identified as the major constituent of total GABA in human CSF. Structural elucidation was done by mass spectrometry. In lumbar CSF of four patients, 2-pyr-rolidinone represented about 54% of GABA found after acid hydrolysis, thus accounting for essentially all of the hitherto unknown GABA fraction in CSF.Keywords
This publication has 18 references indexed in Scilit:
- Free and conjugated CSF and plasma GABA in Huntington's choreaActa Neurologica Scandinavica, 2009
- 2-Pyrrolidinone and succinimide endogenously present in several mammalian speciesLife Sciences, 1984
- Cerebrospinal Fluid GABA as an Index of Brain GABA ActivityClinical Neuropharmacology, 1983
- Concentration Gradients of Free and Total γ‐Aminobutyric Acid and Homocarnosine in Human CSF: Comparison of Suboccipital and Lumbar SamplingJournal of Neurochemistry, 1982
- Artifactual Increases in the Concentration of Free GABA in Samples of Human Cerebrospinal Fluid Are Due to Degradation of HomocarnosineJournal of Neurochemistry, 1982
- Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid)Life Sciences, 1981
- Δ′-Pyrroline: An intermediary metabolite in the conversion of putrescine to 2-pyrrolidoneBiochemical and Biophysical Research Communications, 1980
- Cerebrospinal fluid homocarnosine in Huntington's diseaseLife Sciences, 1980
- ISOLATION AND IDENTIFICATION OF γ‐AMINOBUTYRYL‐CYSTATHIONINE FROM HUMAN BRAIN AND CSFJournal of Neurochemistry, 1977
- On the efficacy of asparagine, glutamine, γ-aminobutyric acid and 2-pyrrolidinone in preventing chemically induced seizures in miceClinica Chimica Acta; International Journal of Clinical Chemistry, 1957