Role of FSH in regulating granulosa cell division and follicular atresia in rats
- 1 November 1978
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 54 (2), 275-278
- https://doi.org/10.1530/jrf.0.0540275
Abstract
The effects of PMSG [pregnant mare''s serum gonadotropin] on the mitotic activity of granulosa cells and atresia of large follicles in 24 day old rats were examined. The labeling index decreased in atretic follicles parallel with a loss of FSH [folitropin] binding, and increased in hypophysectomized rats treated with FSH. FSH stmulates granulosa cell divisions and atresia may be caused by reduced binding of FSH to the granulosa cells.Keywords
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