A Randomized Placebo-Controlled Clinical Trial of 5 Smoking Cessation Pharmacotherapies

Abstract

Many smokers have successfully quit using a variety of smoking cessation pharmacotherapies, yet there is little direct evidence on the relative efficacies of these different pharmacotherapies. Without such evidence clinicians and smokers lack a strong empirical basis for recommending or selecting among them. We report data on the efficacies of 5 different smoking cessation pharmacotherapies. This research also evaluates the efficacy of the nicotine lozenge, providing additional information on a treatment that has been supported by only 1 placebo-controlled study published to date. Finally, this research evaluates 2 different medication combinations, one of which (ie, the nicotine patch plus nicotine lozenge) has not been previously evaluated.