Peroxisome proliferator-activated receptors (PPARs) in health and disease.
Open Access
- 1 December 2002
- journal article
- review article
- Published by Palacky University Olomouc in Biomedical Papers
- Vol. 146 (2), 11-14
- https://doi.org/10.5507/bp.2002.002
Abstract
Peroxisome proliferator-activated receptors (PPARs) belong to the superfamily of steroid-thyroid-retinoid nuclear receptors. PPARs are transcription factors activated by specific ligands and play an important role during cell signalling. Intensive study of PPARs during recent years has revealed their importance in both normal physiology and in the pathology of various tissues. They participate in the regulation of lipid metabolism, inflammation and the development of atherosclerosis or diabetes. They also play a role in the regulation of growth and differentiation of cancer. It has been suggested that PPAR ligands may have potent anticancer effects and thereFirst may serve as potential anticancer drugs. In this review we focus on a role of PPARs in breast cancer and in glial tumors of the brain.Keywords
This publication has 39 references indexed in Scilit:
- Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Mitogenic Induction of p21Cip1 by Modulating the Protein Kinase Cδ Pathway in Vascular Smooth Muscle CellsJournal of Biological Chemistry, 2001
- Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?Current Opinion in Lipidology, 2001
- PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancerTrends in Pharmacological Sciences, 2000
- Peroxisome proliferator‐activated receptors in tumorigenesis: Targets of tumour promotion and treatmentImmunology & Cell Biology, 2000
- Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general populationJournal of Medical Genetics, 2000
- PPAR‐γ‐Mediated Regulation of Normal and Malignant B Lineage CellsAnnals of the New York Academy of Sciences, 2000
- Peroxisome proliferator activated receptor-γ (PPAR-γ) mediates the action of gamma linolenic acid in breast cancer cellsProstaglandins, Leukotrienes & Essential Fatty Acids, 2000
- Terminal Differentiation of Human Breast Cancer through PPARγMolecular Cell, 1998
- 9-cis retinoic acid is a high affinity ligand for the retinoid X receptorCell, 1992
- Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferatorsNature, 1990