Effects of Periodontal Therapy on Rate of Preterm Delivery
- 1 September 2009
- journal article
- research article
- Published by Wolters Kluwer Health in Obstetrics & Gynecology
- Vol. 114 (3), 551-559
- https://doi.org/10.1097/aog.0b013e3181b1341f
Abstract
OBJECTIVE: To test the effects of maternal periodontal disease treatment on the incidence of preterm birth (delivery before 37 weeks of gestation). METHODS: The Maternal Oral Therapy to Reduce Obstetric Risk Study was a randomized, treatment-masked, controlled clinical trial of pregnant women with periodontal disease who were receiving standard obstetric care. Participants were assigned to either a periodontal treatment arm, consisting of scaling and root planing early in the second trimester, or a delayed treatment arm that provided periodontal care after delivery. Pregnancy and maternal periodontal status were followed to delivery and neonatal outcomes until discharge. The primary outcome (gestational age less than 37 weeks) and the secondary outcome (gestational age less than 35 weeks) were analyzed using a χ2 test of equality of two proportions. RESULTS: The study randomized 1,806 patients at three performance sites and completed 1,760 evaluable patients. At baseline, there were no differences comparing the treatment and control arms for any of the periodontal or obstetric measures. The rate of preterm delivery for the treatment group was 13.1% and 11.5% for the control group (P=.316). There were no significant differences when comparing women in the treatment group with those in the control group with regard to the adverse event rate or the major obstetric and neonatal outcomes. CONCLUSION: Periodontal therapy did not reduce the incidence of preterm delivery. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov , www.clinicaltrials.gov , NCT00097656. LEVEL OF EVIDENCE: IKeywords
This publication has 28 references indexed in Scilit:
- Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trialsAmerican Journal of Obstetrics and Gynecology, 2009
- Effect of Periodontal Therapy on Pregnancy Outcome in Women Affected by PeriodontitisThe Journal of Periodontology, 2007
- Periodontal Disease at the Biofilm–Gingival InterfaceThe Journal of Periodontology, 2007
- Periodontal disease and preterm birth: do the data have enough teeth to recommend screening and preventive treatment?American Journal of Obstetrics and Gynecology, 2007
- Preterm low birth weight and maternal periodontal status: a meta-analysisAmerican Journal of Obstetrics and Gynecology, 2007
- Treatment of Periodontal Disease and the Risk of Preterm BirthNew England Journal of Medicine, 2006
- Maternal periodontal disease in early pregnancy and risk for a small-for-gestational-age infantAmerican Journal of Obstetrics and Gynecology, 2006
- Antibiotics for treating bacterial vaginosis in pregnancyPublished by Wiley ,2005
- The Oral Conditions and Pregnancy Study: Periodontal Status of a Cohort of Pregnant WomenThe Journal of Periodontology, 2004
- Socio‐economic disparities in pregnancy outcome: why do the poor fare so poorly?Paediatric and Perinatal Epidemiology, 2000