Donor-site morbidity in 300 consecutive free flaps was reviewed to identify their etiologies and potentially prevent their recurrence in future cases. An overall morbidity rate of 20 percent was seen in this series. Secondary surgical procedures specific for donor-site problems were required in 7.7 percent of patients. Major complications occurred in 2.3 percent of the donor sites. From this review it is apparent that major donor-site morbidity is uncommon and most donor-site problems could probably have been avoided. Our recommendations are as follows: (1) closure of the donor site to avoid excessive tension must be carefully planned preoperatively, (2) donor-site anatomy and flap elevation techniques must be precisely understood, (3) surgical retractors must be carefully placed to avoid injury to nearby structures, (4) the donor site should be closed immediately following pedicle division, thus minimizing wound exposures, and (5) complete surgical hemostasis is mandatory.