Experimental Studies of Factors Influencing Hepatic Metastases. XVIII. Significance of Trapped Tumor Cells.

Abstract

No increase in numbers of intraportally injected Cr51-labeled Walker tumor cells was detected in livers of rats subjected to partial hepatectomy, hepatic manipulation, reticuloendothelial blockade, high fat, choline-free diet, caval constriction, or injection of dextran. This indicates that the augmentation of hepatic metastases produced by these modalities in this model system is related to their metabolic or biologic ("soil") rather than mechanical influences on hepatic-tumor cell relationships.