THE INFLUENCE OF PANCREATECTOMY ON THE METABOLIC STATE OF THE ALLOXAN-DIABETIC DOG

Abstract

Pancreatectomy produces diminution of glycosuria of alloxan-diabetic dogs maintained on a constant dietary intake and insulin dosage. Pancreatectomy produces a decrease in absorption of proteins from the intestinal tract as revealed by the increase in the percentage of dietary protein lost with the feces. Pancreatectomy aggravates the severity of the diabetic state since the hyperglycemia, glycosuria and ketonemia observed during a period of fasting and exogenous insulin deprivation is greater after than before pancreatectomy of the alloxan-diabetic dog. The alloxan-diabetic dog develops a severe ketonemia after phlorhizination and the consequent depletion of hepatic glycogen. The diminished glycosuria following pancreatectomy of the fed alloxan-diabetic dog is attributed to the decreased absorption of carbohydrate precursors which in turn masks the aggravation of the endogenous metabolic derangement.