Effect of Calcium Ion on the Release of γ-Aminobutyric Acid from Synaptosomal Fraction1
- 1 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 92 (6), 1919-1923
- https://doi.org/10.1093/oxfordjournals.jbchem.a134122
Abstract
Brain synaptosomes released endogenous γ-aminobutyric acid (GABA) in response to Ca2+. The release of GABA in response to 2.5 mM Ca2+ increased linearly with log [K+]0, showing that a membrane potential-dependent Ca2+ channel limits the GABA release. In the presence of Ca2+ ionophore, A23187, GABA release increased linearly with log[Ca2+]0 without altering the membrane potential of synaptosomes.Keywords
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