Processing of tRNA in Prokaryotes and Eukaryote
- 1 January 1984
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biochemistry
- Vol. 17 (1), 45-71
- https://doi.org/10.3109/10409238409110269
Abstract
Considerable progress has been made in defining the steps in the conversion of a tRNA precursor to a mature tRNA. These steps, which differ in different systems, include removal of precursor-specific residues from the 5' and 3' termini of the initial transcript, addition of the 3'-C-C-A terminus, splicing of intervening sequences, and modification of nucleotide residues. Despite these advances in defining the "pathways" of tRNA processing, relatively little is known about most of the enzymes actually involved in these processing steps. In this article I describe the sequence of reactions needed to convert the initial tRNA transcript to a functional, mature tRNA, and discuss the specificity and properties of enzymes known to be involved in this process. In addition, I speculate on the expected specificities of other enzymes involved in tRNA processing which have not yet been identified, and on the structural organization of the processing machinery.Keywords
This publication has 76 references indexed in Scilit:
- An RNA species involved in Escherichia coli ribonuclease P activityJournal of Molecular Biology, 1982
- A small RNA that complements mutants in the RNA processing enzyme ribonuclease PJournal of Molecular Biology, 1982
- The transfer RNA processing defect in Escherichia coli strains BN and CAN is not due to a mutation in RNAase D or RNAase IIJournal of Molecular Biology, 1982
- Processing of bacteriophage T4 transfer RNAs structural analysis and In Vitro processing of precursors that accumulate in RNase E− strainsJournal of Molecular Biology, 1982
- Ribonuclease F, a putative processing endoribonuclease from Escherichia coliBiochemical and Biophysical Research Communications, 1981
- Alteration of Escherichiacoli RNase D by infection with bacteriophage T4Biochemical and Biophysical Research Communications, 1981
- DNA sequence of a T4 transfer RNA gene clusterJournal of Molecular Biology, 1980
- Asymmetric maturation of a dimeric transfer RNA precursorJournal of Molecular Biology, 1980
- Identification of RNA molecules which contain 5 S ribosomal RNA and transfer RNA in an RNAase E− RNAase P− double mutant strain of Escherichia coliJournal of Molecular Biology, 1980
- Evolution of the biosynthesis of 3′-terminal C-C-A residues in T-even bacteriophage transfer RNAsJournal of Molecular Biology, 1978