Synthesis of a [2-Pyridinyl-18F]-labelled fluoro derivative of (−)-Cytisine as a candidate radioligand for brain nicotinic α4β2 receptor imaging with PET
- 1 December 2003
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 11 (24), 5333-5343
- https://doi.org/10.1016/j.bmc.2003.09.042
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activitiesIl Farmaco, 2003
- SIC: an intracerebral radiosensitive probe for in vivo neuropharmacology investigations in small laboratory animals: prototype design, characterization, and in vivo evaluationIEEE Transactions on Nuclear Science, 2002
- 5‐Iodo‐A‐85380 binds to α‐conotoxin MII‐sensitive nicotinic acetylcholine receptors (nAChRs) as well as α4β2* subtypesJournal of Neurochemistry, 2002
- 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, Affinity for Nicotinic Acetylcholine Receptors, and Molecular ModelingJournal of Medicinal Chemistry, 1998
- 5-[I- ]Iodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptorsLife Sciences, 1998
- Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine ReceptorsJournal of Medicinal Chemistry, 1998
- A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In Vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligandNeuropharmacology, 1996
- In vivo labeling of nicotinic cholinergic receptors in brain with [3H]cytisineLife Sciences, 1994
- Stereospecific Nicotine Receptors on Rat Brain MembranesScience, 1980
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973