Effect of Antioxidants on Muscle and Plasma Lipids of Vit. E-deficient Guinea Pigs.

Abstract

In guinea pigs with muscular dystrophy induced by the feeding of a highly purified vitamin E-deficient diet containing no cod liver oil, there was a rise in cholesterol levels of plasma and skeletal muscle and in muscle total lipid; these increases preceded the onset of dystrophy. Supplementation of the vitamin E-deficient ration with the antioxidants DPPD (N,N''-di-phenyl-p-phenylenediamine), BHT (butylated hydroxytoluene), DBH (2,5-di-t-butylhydroquinone) and Santoquin (6-ethoxy-2,2,4-trimethyl-l,2-dihydro-quinoline), although delaying onset of dystrophy symptoms, did not prevent the rise in plasma and muscle cholesterol and muscle total lipid produced by vitamin E deficiency.