The in Vitro and in Vivo Effects of Cortisol on Interferon Production and Action
- 31 January 1966
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 96 (2), 345-352
- https://doi.org/10.4049/jimmunol.96.2.345
Abstract
Using the plaque reduction assay for interferon, it was found that cortisol inhibited inter feron production in infections with either an RNA (Chikungunya) or a DNA (vaccinia) virus in vitro. The depression of interferon production was not associated with an increased rate of virus replication. There was no effect of cortisol on the anti-viral activity of interferon in vitro. In vivo, the injection of cortisol 1 hr before an experimental viremia significantly reduced the amount of interferon in the sera of mice 4.5 to 6 hr after infection.This publication has 19 references indexed in Scilit:
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