Effect of Mercurial Diuretics Upon Oxidative Phosphorylation in Rat Kidney Mitochondria
- 28 February 1958
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 192 (3), 599-602
- https://doi.org/10.1152/ajplegacy.1958.192.3.599
Abstract
Administration of large doses of Hg203-labeled chlormerodrin to rats does not lower the P/O ratio of isolated kidney mitochondria. In vitro addition of chlormerodrin will lower the P/O ratio of rat kidney mitochondria, but only in concentrations greater than can be found by measurement of the mitochondrial radiomercury content following intramuscular injection. These techniques fail to demonstrate an in vivo effect of chlormerodrin upon oxidative phosphorylation by rat kidney mitochondria.Keywords
This publication has 12 references indexed in Scilit:
- THE UNCOUPLING OF OXIDATIVE PHOSPHORYLATION AS A MECHANISM OF DRUG ACTION1955
- Mechanism of Action of Mercurial Diuretics II.Experimental Biology and Medicine, 1954
- THE INFLUENCE OF MERSALYL ON PHOSPHATE METABOLISM IN KIDNEY SLICES FROM INTRAVENOUSLY INJECTED RATS1954
- THE CATALYTIC EFFECT OF 2,4-DINITROPHENOL ON ADENOSINETRIPHOSPHATE HYDROLYSIS BY CELL PARTICLES AND SOLUBLE ENZYMESJournal of Biological Chemistry, 1953
- ON THE MECHANISM OF ACTION OF MERCURIAL DIURETICS1953
- STUDIES ON DIURETICS. I. THE SITE OF ACTION OF MERCURIAL DIURETICS 1JCI Insight, 1950
- RENAL HEMODYNAMIC CHANGES PRODUCED BY MORPHINE IN NORMAL DOGS AND DOGS WITH DIABETES INSIPIDUS1950
- STUDIES ON THE CYCLOPHORASE SYSTEM .6. THE COUPLING OF OXIDATION AND PHOSPHORYLATION1949
- THE INFLUENCE OF SULFHYDRYL COMPOUNDS ON DIURESIS AND RENAL AND CARDIAC CIRCULATORY CHANGES CAUSED BY MERSALYL1948
- THE DETERMINATION OF INORGANIC PHOSPHATE IN THE PRESENCE OF LABILE PHOSPHATE ESTERSJournal of Biological Chemistry, 1946