DEGRADATION OF A NONAPEPTIDE, SLEEP INDUCING PEPTIDE, IN RAT-BRAIN - COMPARISON WITH ENKEPHALIN BREAKDOWN
- 1 January 1978
- journal article
- research article
- Vol. 19 (2), 191-199
Abstract
The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of met-enkephalin in brain homogenates. After 7.5 min of incubation of 2.5% (wt/vol) homogenate, 30% of N-terminal tryptohan was released from DSIP, while 75% of N-terminal tryosine was released from met-enkephalin. The optimal pH of degradation of both peptides was pH 7.35. A rapid increase of breakdown of the peptides was observed during the 10 days of postnatal growth, with breakdown expressed per unit weight of brain. Neither morphine nor deprivation of rapid eye movement (REM) sleep affected the degradation of peptides.This publication has 6 references indexed in Scilit:
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