Carcinoembryonic Antigen in Hereditary Adenomatosis of the Colon and Rectum
- 1 November 1975
- journal article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 10 (8), 875-879
- https://doi.org/10.1080/00365521.1975.12097063
Abstract
Hereditary adenomatosis of the colon and rectum (ACR) invariably leads to malignant transformation unless the patients undergo prophylactic operations. The serum level of carcinoembryonic antigen (CEA) was determined in 130 individuals belonging to different ACR-families. Fifty-six of them were operated upon with colectomy, 27 affected individuals were still not operated on, and 47 were unaffected first degree relatives. Around 20 percent of the patients in each of these groups had moderately raised CEA serum levels compared to unrelated healthy subjects. Since the serum values were low or only moderately raised and occurred in all groups, the determination of serum levels cannot be generally used to indicate malignant transformation of adenomas. However, assays of the tissue CEA content in six histologically verified adenomas showed values similar to those of overt colonic carcinomas. This opens up stimulating possibilities of investigating the CEA activity in serum and tissues of chosen individuals with ACR.Keywords
This publication has 18 references indexed in Scilit:
- DETECTION OF RECURRENCE OF LARGE-BOWEL CARCINOMA BY RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN (C.E.A.)The Lancet, 1974
- Carcinoembryonic antigenic activity of tissue extracts: A quantitative study of malignant and benign neoplasms, cirrhotic liver, normal adult and fetal organsInternational Journal of Cancer, 1973
- Carcinoembryonic Antigen (CEA) in non digestive cancerous and normal tissuesImmunochemistry, 1973
- Carcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor‐cell differentiationInternational Journal of Cancer, 1972
- The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissueImmunochemistry, 1972
- Isolation and characterization for carcinoembryonic antigenImmunochemistry, 1972
- Polyposis of the stomach and small intestine in association with familial polyposis coliBritish Journal of Surgery, 1971
- SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEMThe Journal of Experimental Medicine, 1965
- Malignant tumors of the central nervous system associated with familial polyposis of the colonDiseases of the Colon & Rectum, 1959