Saniculoside N from Sanicula europaea L.

Abstract

Extracts from the aerial parts of Sanicula europaea L. were investigated for their anti-HIV activity, and the 50% ethanolic extract was shown to exhibit the highest activity. A new triterpene saponin glycoside, 21β-(angeloyloxy)-3-O-[β-d-arabinopyranosyl(1→4)-β-d-glucopyranosyl(1→3)-β-d-glucuronopyranosyl propyl ester]-3β,15,16,22α,28β-pentahydroxy-Δ¹²-oleanene, saniculoside N (1), in addition to the known phenolic acids, rosmarinic acid (2), and caffeic acid (3) were isolated as major components. Rosmarinic acid was established as the principal active substance.