Stimulation of Fetal Hemoglobin Synthesis by Erythropoietin in Baboons
- 13 August 1987
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 317 (7), 415-420
- https://doi.org/10.1056/nejm198708133170704
Abstract
Stimulating the production of fetal hemoglobin may benefit patients with sickle cell anemia by inhibiting sickling. We gave pulsed treatments with high doses of recombinant human erythropoietin to baboons in order to test the hypothesis that the resultant rapid erythroid regeneration would stimulate F cells — i.e., cells that contain fetal hemoglobin.This publication has 36 references indexed in Scilit:
- Correction of the Anemia of End-Stage Renal Disease with Recombinant Human ErythropoietinNew England Journal of Medicine, 1987
- EFFECT OF HUMAN ERYTHROPOIETIN DERIVED FROM RECOMBINANT DNA ON THE ANAEMIA OF PATIENTS MAINTAINED BY CHRONIC HAEMODIALYSISThe Lancet, 1986
- Stimulation of F-Cell Production in Patients with Sickle-Cell Anemia Treated with Cytarabine or HydroxyureaNew England Journal of Medicine, 1985
- Pharmacological Manipulation of Fetal Hemoglobin Synthesis in Patients with Severe β‐ThalassemiaAnnals of the New York Academy of Sciences, 1985
- Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.Journal of Clinical Investigation, 1984
- Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by HydroxyureaNew England Journal of Medicine, 1984
- 5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+ThalassemiaNew England Journal of Medicine, 1982
- Cellular Distribution of Hemoglobin F in a Clonal Hemopoietic Stem-Cell DisorderNew England Journal of Medicine, 1978
- Activation of Hemoglobin C Synthesis in Sheep Marrow CultureScience, 1973
- On the in vivo action of erythropoietin: a quantitative analysisJournal of Clinical Investigation, 1972