The in-vitro activity of PD127,391, a new quinolone

Abstract

MICs of PD127,391 a new 4-quinolone, and of CI934 and ciprofloxacin, two previously reported 4-quinolones, were determined for common clinical bacterial isolates by an agar-dilution method. PD127,391 was the most active drug against Enterobacteriaceac and Acinetobacter spp (MICs Aeromonas spp. (MICs Pseudomonas aeruginosa (MICs Pseudomonas spp. including Ps. maltophilia (MICs Haemophilus influenzae Brahmamella catarrhalis, and Neisseria gonorrhoeae. PD127,391 was much more active than the other drugs against Campylobacter coliljejuni (PD127,391 MICs Gardnerella vaginalis (PD127,391 MICs Bacteroides spp. and clostridia (including Clostridium difficile) (MICs <1 mg/l) than was CI934 (MICs <16 mg/l) or ciprofloxacin (MICs <64 mg/l). No bacterium that we examined required more than 1 mg/l of PD127,391 for inhibition, and there was no cross resistance with unrelated antibiotics.