Myo-inositol in the Biosynthesis of Streptomycin by Streptomyces griseus
- 2 March 1962
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 135 (3505), 734
- https://doi.org/10.1126/science.135.3505.734
Abstract
When myo-inositol is present in a growing culture of Streptomyces griseus the yield of streptomycin is increased, and the amount of carbon-14—from uniformly labeled glucose—incorporated into the streptidine and streptobiosamine moieties of streptomycin is lowered by 41 percent and 21.7 percent, respectively. These results present strong indirect evidence for the participation of myo-inositol or its metabolic products in streptidine biosynthesis.Keywords
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