ENDOSCOPIC EVALUATION OF THE COMPARATIVE EFFECTS OF ACETYLSALICYCLIC ACID AND CHOLINE MAGNESIUM TRISALICYLATE ON HUMAN GASTRIC AND DUODENAL MUCOSA

Abstract

A new salicylate product, choline magnesium trisalicylate (Trilisate^® tablets), and acetylsalicylic acid were compared for their local effects in equipotent doses on the gastroduodenal mucosa in a randomized, double-blind, cross-over study, using 10 healthy volunteers. After five-day periods of administration, gastroduodenoscopy was performed and photographs were obtained. All subjects given acetylsalicylic acid developed multiple mucosal lesions, but in only four subjects given choline magnesum trisalicylate were slight mucosal changes noted. Mean serum salicylate levels were similar in the two groups. Our date suggest that the risk of developing mucosal lesions is much less during treatment with choline magnesium trisalicylate than with acetylsalicylic acid.