Further Experiments on Influence of Hyaluronidase on Formation of Intraperitoneal Adhesions in the Rat

Abstract

Adhesions were produced in the rat by mechanical trauma to the wall of the cecum by 3 standardized methods. The effect of 3 hyaluronidase prepns. applied locally to the injured area at the time of laparotomy was tested. One prepn. was tested against 2 types of injury and the other 2 prepn. were tested against a 3d type of injury. The results were negative in that no statistically significant differences were obtained between animals treated with hyaluronidase prepn. and the untreated controls.