Cyclosporine-Associated Central-Nervous-System Toxicity after Allogeneic Bone-Marrow Transplantation

Abstract

To the Editor: Cyclosporine has proved to be a useful drug in the prevention of graft rejection after solid-organ transplantation^{1 2 3} and is effective in the prevention of graft-versus-host disease after bone-marrow transplantation.⁴ Renal^{5 , 6} and hepatic^{7 , 8} toxicity have been noted, and tremor is a commonly observed side effect of this drug. We wish to draw attention to previously unemphasized, serious neurotoxicity associated witli the use of cyclosporine. In a series of 64 consecutive recipients of allogeneic marrow transplants who were immunosuppressed with cyclosporine, 5 had serious neurotoxicity. All five patients underwent transplantation for hematologic cancer and were conditioned with cyclophosphamide (60 . . .